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pentobarbital will lessen the level or outcome of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to the reduce in fentanyl plasma concentrations, lack of efficacy or, perhaps, advancement of a withdrawal syndrome in a client who may h